13October2019

Nano-Micro Letters

Fluorescent Silicon Nanorods-Based Nanotheranostic Agents for Multimodal Imaging-Guided Photothermal Therapy

Mingyue Cui1, Sangmo Liu1, Bin Song1, Daoxia Guo1, Jinhua Wang1, Guyue Hu1, Yuanyuan Su1, *, Yao He1, *

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Nano-Micro Lett. (2019) 11: 73

First Online: 09 September 2019 (Article)

DOI:10.1007/s40820-019-0306-9

*Corresponding author. E-mail: suyuanyuan@suda.edu.cn (Yuanyuan Su); yaohe@suda.edu.cn (Yao He)

 

Abstract

 


Toc

The utilization of diagnosis to guide/aid therapy procedures has shown great prospects in the era of personalized medicine along with the recognition of tumor heterogeneity and complexity. Herein, a kind of multifunctional silicon-based nanostructure, i.e., gold nanoparticles-decorated fluorescent silicon nanorods (Au@SiNRs), is fabricated and exploited for tumor-targeted multimodal imaging-guided photothermal therapy. In particular, the prepared Au@SiNRs feature high photothermal conversion efficiency (~ 43.9%) and strong photothermal stability (photothermal performance stays constant after five-cycle NIR laser irradiation), making them high-performance agents for simultaneously photoacoustic and infrared thermal imaging. The Au@SiNRs are readily modified with targeting peptide ligands, enabling an enhanced tumor accumulation with a high value of ~ 8.74% ID g-1. Taking advantages of these unique merits, the Au@SiNRs are superbly suitable for specifically ablating tumors in vivo without appreciable toxicity under the guidance of multimodal imaging. Typically, all the mice treated with the Au@SiNRs remain alive and no distinct tumor recurrence is observed during 60-day investigation.


 

Keywords

Fluorescent silicon nanorods; Multimodal imaging; Targeted; Photothermal therapy; Tumor

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