13October2019

Nano-Micro Letters

Inorganic Nanozyme with Combined Self-Oxygenation/Degradable Capabilities for Sensitized Cancer Immunochemotherapy

Jie Wang1, Lan Fang1, Ping Li1, Lang Ma2, 3, Weidan Na1, Chong Cheng2, 3, *, Yueqing Gu1, Dawei Deng1, 4, *

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Nano-Micro Lett. (2019) 11: 74

First Online: 09 September 2019 (Article)

DOI:10.1007/s40820-019-0305-x

*Corresponding author. E-mail: dengdawei@cpu.edu.cn (D. Deng); chong.cheng@fu-berlin.de (C. Cheng)

 

Abstract

 


Toc

Recently emerged cancer immunochemotherapy has provided enormous new possibilities to replace traditional chemotherapy in fighting tumor due to their synergistic effects. However, the treatment efficacy is hampered by tumor hypoxia-induced immunosuppression in tumor microenvironment (TME). Herein, we report to fabricate a self-oxygenation/degradable inorganic nanozyme with a core-shell structure to relieve tumor hypoxia in cancer immunochemotherapy. By integrating the biocompatible CaO2 as the oxygen-storing component, our strategy is found to be more effective than the earlier designed nanocarriers for delivering oxygen or H2O2, and thus provides remarkable oxygenation and long-term capability in relieving hypoxia throughout the tumor tissue. Consequently, in vivo tests validate that our delivery system can successfully relieve hypoxia and reverse the immunosuppressive TME to favor antitumor immune responses, leading to enhanced chemoimmunotherapy with cytotoxic T lymphocyte-associated antigen 4 blockade. Overall, for the first time, a facile, robust, and effective strategy has been proposed to improve tumor oxygenation by using self-decomposable and biocompatible inorganic nanozyme reactor, which will not only provide an innovative pathway to relieve intratumor hypoxia, but also present potential applications in other oxygen-favored cancer therapies or oxygen deficiency-originated diseases.


 

Keywords

Inorganic nanozyme; Self-oxygenation nanoreactor; Biodegradable nanomedicine; Immunochemotherapy; Cancer treatment

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