Nano-Micro Letters

Cell Membrane Coating Technology: A Promising Strategy for Biomedical Applications

Yao Liu1, 2, Jingshan Luo1, 2, Xiaojia Chen3, Wei Liu4, *, Tongkai Chen1, 2, *

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Nano-Micro Lett. (2019) 11: 100

First Online: 16 November 2019 (Review)


*Corresponding author. E-mail: (Tongkai Chen); (Wei Liu)





Cell membrane coating technology is an approach to the biomimetic replication of cell membrane properties, and is an active area of ongoing research readily applicable to nanoscale biomedicine. Nanoparticles (NPs) coated with cell membranes offer an opportunity to unite natural cell membrane properties with those of the artificial inner core material. The coated NPs not only increase their biocompatibility but also achieve effective and extended circulation in vivo, allowing for the execution of targeted functions. Although cell membrane-coated NPs offer clear advantages, much work remains before they can be applied in clinical practice. In this review, we first provide a comprehensive overview of the theory of cell membrane coating technology, followed by a summary of the existing preparation and characterization techniques. Next, we focus on the functions and applications of various cell membrane types. In addition, we collate model drugs used in cell membrane coating technology, and review the patent applications related to this technology from the past ten years. Finally, we survey future challenges and trends pertaining to this technology in an effort to provide a comprehensive overview of the future development of cell membrane coating technology.



Cell membrane; Biomimetic nanoparticles; Cancer therapy; Immune modulation; Detoxification

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