15November2019

Nano-Micro Letters

Correction to: Fluorescent Silicon Nanorods‑Based Nanotheranostic Agents for Multimodal Imaging‑Guided Photothermal Therapy

Mingyue Cui1, Sangmo Liu1, Bin Song1, Daoxia Guo1, Jinhua Wang1, Guyue Hu1, Yuanyuan Su1,*, Yao He1,*

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1Laboratory of Nanoscale Biochemical Analysis, Institute of Functional Nano & Soft Materials (FUNSOM), and Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, People’s Republic of China

Nano-Micro Lett. (2019) 11: 85

First Online: 15 October 2019 (Correction)

DOI:10.1007/s40820-019-0318-5

*Corresponding author. E-mail: suyuanyuan@suda.edu.cn (Yuanyuan Su); yaohe@suda.edu.cn (Yao He)

  

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1 Correction to: Nano-Micro Lett. (2019) 11:73  https://doi.org/10.1007/s40820-019-0306-9
In the original publication figures 3b, 5a, 5g are incorrectly published and the scale bars in figures 4b and 4d have not appeared.

Fig. 3 Assessment of the biocompatibility, targeted imaging, and photothermal effect in vitro. a Cytotoxicity of PEG-Au@SiNRs. b LSCM images of CT-26 and 4T1 cells after incubation with RGD-Au@SiNRs (blocking with free peptides or not) or Au@SiNRs for 2 h at 37 °C. Scale bars, 25 μm. c Cell viability of CT-26 cells, which were first incubated with RGD-Au@SiNRs or Au@SiNRs for 4 h and then irradiated by an 808-nm laser (0.8 W cm−2) for 5 min as mean ± SD (n = 3). Asterisk (**) indicates p 0.01

Fig. 3 Assessment of the biocompatibility, targeted imaging, and photothermal effect in vitro. a Cytotoxicity of PEG-Au@SiNRs. b LSCM images of CT-26 and 4T1 cells after incubation with RGD-Au@SiNRs (blocking with free peptides or not) or Au@SiNRs for 2 h at 37 °C. Scale bars, 25 μm. c Cell viability of CT-26 cells, which were first incubated with RGD-Au@SiNRs or Au@SiNRs for 4 h and then irradiated by an 808-nm laser (0.8 W cm−2) for 5 min as mean ± SD (n = 3). Asterisk (**) indicates p 0.01

Fig. 4 Tumor-targeted multimodal imaging in vivo. a Schematic illustration of the active targeting of RGD-Au@SiNRs. b PA imaging and c the corresponding PA signal intensity of tumor regions of CT-26 tumor-bearing mice untreated and treated with RGD-Au@SiNRs, Au@SiNRs, or PBS for 12 and 24 h. d Infrared thermal mapping images, and e corresponding temperature change of tumor regions of CT-26 tumor-bearing mice irradiated with an 808-nm laser (0.8 W cm−2) for different times (0–8 min, time interval: 30 s) at 24 h post-administration with RGD-Au@SiNRs, Au@SiNRs, or PBS. f LSCM images of tumor sections at 24 h post-injection of PBS, Au@SiNRs, or RGD-Au@SiNRs. Scale bars, 100 μm, and g corresponding quantitative analysis of the fluorescence intensity. h The bio-distribution of RGD-Au@SiNRs and Au@SiNRs measured by ICP-OES at 24 h post-administration. Asterisk (**) indicates p 0.01; (***) means p 0.001

Fig. 4 Tumor-targeted multimodal imaging in vivo. a Schematic illustration of the active targeting of RGD-Au@SiNRs. b PA imaging and c the corresponding PA signal intensity of tumor regions of CT-26 tumor-bearing mice untreated and treated with RGD-Au@SiNRs, Au@SiNRs, or PBS for 12 and 24 h. d Infrared thermal mapping images, and e corresponding temperature change of tumor regions of CT-26 tumor-bearing mice irradiated with an 808-nm laser (0.8 W cm−2) for different times (0–8 min, time interval: 30 s) at 24 h post-administration with RGD-Au@SiNRs, Au@SiNRs, or PBS. f LSCM images of tumor sections at 24 h post-injection of PBS, Au@SiNRs, or RGD-Au@SiNRs. Scale bars, 100 μm, and g corresponding quantitative analysis of the fluorescence intensity. h The bio-distribution of RGD-Au@SiNRs and Au@SiNRs measured by ICP-OES at 24 h post-administration. Asterisk (**) indicates p 0.01; (***) means p 0.001

Fig. 5 Photothermal therapy and safety assessment. a Photographs of representative mice before and after the treatment with different agents and NIR irradiation. b Growth curves of tumor volumes of mice groups with NIR irradiation. c Weight of the excised tumors from the PTT-treated mice. d Survival curves of PTT-treated mice. e Serum biochemistry data including alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase, and blood urea nitrogen levels of control and RGD-Au@SiNRs-treated healthy mice. f Complete blood counts: hematocrit, hemoglobin, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, mean corpuscular volume, blood platelets, red blood cells, blood levels of white blood cells, and platelets of control and RGD-Au@SiNRs-treated healthy mice. g H and E staining of various organ tissues harvested from tumor-bearing mice at the end of treatment. Asterisk (**) indicates p 0.01; (***) means p 0.001

Fig. 5 Photothermal therapy and safety assessment. a Photographs of representative mice before and after the treatment with different agents and NIR irradiation. b Growth curves of tumor volumes of mice groups with NIR irradiation. c Weight of the excised tumors from the PTT-treated mice. d Survival curves of PTT-treated mice. e Serum biochemistry data including alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase, and blood urea nitrogen levels of control and RGD-Au@SiNRs-treated healthy mice. f Complete blood counts: hematocrit, hemoglobin, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, mean corpuscular volume, blood platelets, red blood cells, blood levels of white blood cells, and platelets of control and RGD-Au@SiNRs-treated healthy mice. g H and E staining of various organ tissues harvested from tumor-bearing mice at the end of treatment. Asterisk (**) indicates p 0.01; (***) means p 0.001

The correct figures are provided in this correction.
The original article has been corrected.


Additional Info

  • Type of Publishing: JOUR - Journal
  • Title: Correction to: Fluorescent Silicon Nanorods‑Based Nanotheranostic Agents for Multimodal Imaging‑Guided Photothermal Therapy
  • Author: Mingyue Cui, Sangmo Liu, Bin Song, Daoxia Guo, Jinhua Wang, Guyue Hu, Yuanyuan Su, Yao He
  • Year: 2019
  • Volume: 11
  • Journal Name: Nano-Micro Letters
  • ISSN: 2150-5551
  • URL: http://dx.doi.org/10.1007/s40820-019-0318-5
  • Publish Date: Tuesday, 15 October 2019
  • Start Page: 85
  • DOI: 10.1007/s40820-019-0318-5